Copaiba
Copaifera officinalis (Fabaceae)
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| Many species of this genus, from bushes to trees contain the valuable oleoresin, which is extracted from incisions made in the base of the tree. It “exhibited moderate cytotoxic activity against four cancer cell lines,” (University of Bio Organics, Spain). For inflammation, it is applied directly to the site (3, p81; 8, p21). A decoction of the bark for baths is made in Venezuela for rheumatism (2, p224). Copaiba oil is mixed with honey and swallowed for throat ailments (3, p81; 2, p224), for stomach ulcers (2, p224;3, p81), sinusitis (2, p224; 8, p21), inflammation of kidneys and cystitis (2, p224), for urinary incontinence, as a diuretic and laxative. There is also reference to it as antirheumatic, expectorant and contraceptive.(2, p224) |
 Suggested
retail:
 1oz. Liquid Extract Copaiba (Oil, Resin & Bark): $9.95
1 Liter Liquid Extract Copaiba (Oil, Resin & Bark): $99.95
Suggested Use: Liquids: Use 5-10 drops mixed with water one to two times daily or as recommended by a practitioner.
Cautions: Use under care/advice of a medical practitioner. Not intended for long term therapy. Do not use more than recommended.
Contraindications: May cause irritation if applied to the skin or taken internally. Can irritate mucus membranes in some people. Not intended for long-term use. Not intended for pregnant or nursing women. Keep out of the reach of children.
Ingredients: 100% Copaiba oil extracted from the trunk.
More About Copaiba:
2. Antimicrobial terpenoids from the oleoresin of the Peruvian medicinal plant Copaifera paupera.
Tincusi BM, Jimenez IA, Bazzocchi IL, Moujir LM, Mamani ZA, Barroso JP, Ravelo AG, Hernandez BV.
Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, La Laguna, Tenerife, Spain.
Twelve known diterpenes 1 - 11 and 13, and three known sesquiterpenes 14 - 16, along with a new C(20) - C(15) terpenoid 17, with a structure based on an unprecedented skeleton in which a labdane diterpene is linked to a monocyclic sesquiterpene by an ester bridge, were isolated from the oleoresin of the Peruvian medicinal plant Copaifera paupera (Herzog) Dwyer (Leguminosae). Their structures were elucidated on the basis of spectral analysis, including homo- and heteronuclear correlation NMR experiments (COSY, ROESY, HMQC and HMBC), and by comparison with data in the literature. The leishmanicidal, antimicrobial, cytotoxic, and aldose reductase inhibitory activities were studied. Compounds 1 and 11 showed significant antimicrobial activity (MIC < 10 microg/ml) against Gram-positive bacteria, comparable with cephotaxime used as control. Compound 2 exhibited moderate cytotoxic activity against four cancer cell lines.
PMID: 12357392 [PubMed - indexed for MEDLINE]
Basile, A. C., et al. “Anti-inflammatory activity of oleoresin from Brazilian Copaifera.” J. Ethnopharmacol. 1988; 22: 101-9. de Alencar Cunha, K. M., et al. “Smooth muscle relaxant effect of kaurenoic acid, a diterpene from Copaifera langsdorffii on rat uterus in vitro.” Phytother. Res. 2003; 17(4): 320-4.
Veiga, V. F., et al. “Phytochemical and antioedematogenic studies of commercial copaiba oils available in Brazil.” Phytother. Res. 2001; 15(6): 476-80.
Ghelardini, C., et al. “Local anaesthetic activity of beta-caryophyllene.” Farmaco 2001; 56(5-7): 387-89.
Yang, D., et al. “Use of caryophyllene oxide as an antifungal agent in an in vitro experimental model of onychomycosis.” Mycopathologia 1999; 148(2): 79-82.
Paiva, L. A., et al. “Gastroprotective effect of Copifera langsdorffii oleo-resin on experimental gastric ulcer models in rats.” J. Ethnopharmacol. 1998; 62(1): 73-8.
Maruzzella, J. C., et al. “Antibacterial activity of essential oil vapors.” J. Am. Pharm. Assoc. 1960; 49: 692-94.
Tincusi, B. M., et al. “Antimicrobial terpenoids from the oleoresin of the Peruvian medicinal plant Copaifera paupera.” Planta Med. 2002; 68(9): 808-12.e Almeida Alves, T. M., et al. “Biological screening of Brazilian medicinal plants.”Mem. Inst. Oswaldo Cruz 2000; 95(3): 367-73.
Wilkins, M., et al. “Characterization of the bactericidal activity of the natural diterpene kaurenoic acid.” Planta Med. 2002 68(5): 452-54.
Davino, S. C., et al. “Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15.” Braz. J. Med. Biol. Res. 1989; 22(9): 1127-29.
Ohsaki, A., et al. “The isolation and in vivo potent antitumor activity of clerodane diterpenoids from the oleoresin of Brazilian medicinal plant Copaifera langsdorffii Desfon.” Bioorg. Med. Chem. Lett. 1994; 4: 2889-92.
Costa-Lotufo, L. V., et al. “The cytotoxic and embryotoxic effects of kaurenoic acid, a diterpene isolated from Copaifera langsdorffi.” Toxicon 2002; 40(8): 1231-34.
Batista, R., et al. “Trypanosomicidal kaurane diterpenes from Widelia paludosa.” Planta Medica 1999; 65: 283-84.
Valencia, A., et al. “Zoapatle XII. In vitro effect of kaurenoic acid isolated from Montana frutescens and two derivatives
upon human spermatozoa.” J. Ethnopharmcol. 1986; 18(1):
Disclaimer: Statements on this page have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Information on this publication should not be used as medical advice. Data prvided for research and professional use only.
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